nb uvb therapy vs methotrexate on il17and il23 in psoriasis



NB-UVB Therapy vs Methotrexate on IL17and IL23 in psoriasis NB-UVB Therapy vs Methotrexate on IL17and IL23 in psoriasis Новинка

NB-UVB Therapy vs Methotrexate on IL17and IL23 in psoriasis

There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis in the pathogenesis of psoriasis. Objectives. To compare the effect of narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels of IL-17 and IL-23 in psoriatic patients. Methods. Thirty patients with severe plaque psoriasis were included: 15 patients received NB-UVB three times weekly (group I) and 15 patients received MTX 0.3?mg/kg per week (group II), both for 8 weeks. Before and after treatment, serum levels of IL-17 and IL-23 were investigated by ELISA technique and psoriasis area and severity index (PASI) was calculated. Results. After treatment, all patients showed a reduction in their PASI score, IL-17 and IL-23 serum levels with a nonsignificant difference between both therapeutic modalities . A positive correlation was detected between the percent of reduction of IL-17, IL-23 and the percent of reduction of PASI score for patients receiving both treatments. Conclusion. Interleukin-17 and IL-23 serum level may serve as a potential biomarker for predicting the prognosis and therapeutic response of NB-UVB or MTX in treating psoriasis.
Microemulsion- A novel drug delivery system Microemulsion- A novel drug delivery system Новинка

Microemulsion- A novel drug delivery system

Purpose of the study is to develope stable Methotrexate (MTX) loaded Microemulsion based formulation for topical treatment of Psoriasis with improvement in cutaneous deposition and to enhance the local effect. Several treatments of psoriasis are available, each specifically related to certain factors but none of these have curative effects. For practical purposes, patients with less than 15 % body surface involvement can be treated effectively with topical agents. In last few decades there is increasing in understandings of skin & its barrier properties which allowed development of more efficient means of delivering drugs through skin. Methotrexate has been shown to selectively inhibit DNA synthesis in psoriatic epidermal cells, thus decreasing mitotic activity. Localization of MTX in effected layers of skin is likely to improve the role of topical dosage form of drug as a supplementary to oral therapy for treatment of psoriasis. In recent years, Microemulsion is recognized as one good vehicle for the percutaneous absorption of drugs. So in present study, attempt was made for finding powerful formulation of poorly soluble MTX for topical treatment of Psoriasis.
Quality of life assessment in psoriasis patients Quality of life assessment in psoriasis patients Новинка

Quality of life assessment in psoriasis patients

Psoriasis is a disease with profound impact on the psychological and social aspect of the patient, particularly because of its visibility. Assessment of psoriasis severity requires a more holistic approach which encompasses both clinical and psychological measures and not merely the clinical severity assessment in isolation. This study has highlighted the importance of adopting a multidimensional assessment of quality of life in psoriasis. The findings of this study may also have important implications in measurement of efficacy of dermatologic therapy and in adjunctive stress management approaches in the clinical management of psoriasis. This study concludes that, psoriasis has a significant negative impact on physical, emotional and psychological wellbeing of the affected patients, thus causing a substantial impact on patient’s Quality of life. In view of this, it is very important to evaluate quality of life of psoriasis patients and also screen the patients for associated psychiatric co-morbid conditions like anxiety and depression, before making therapeutic decision
Biologics for Psoriasis in Iraq: Benefits & Barriers Biologics for Psoriasis in Iraq: Benefits & Barriers Новинка

Biologics for Psoriasis in Iraq: Benefits & Barriers

Introduction of these drugs in treating patients with psoriasis in some of the hospitals in Baghdad will help those patients a lot, improving their quality of life and decreasing the morbidity caused by psoriasis and many of the conventional drugs used to treat it. They could be introduced for those for whom many of these conventional drugs are ineffective or contraindicated as a result of their effects on different organs of the body. The aim of this project is to explore the feasibility and the possibility of the introduction of biological drugs as one of the treatment options for psoriasis in Alkarama teaching hospital in Baghdad. This project has many objectives. Firstly, to assess the readiness of hospitals in Baghdad for the introduction of biological drugs. Secondly, to try to establish the suitability of using biological drugs for psoriasis in Iraq. Thirdly, to decrease the cumulative side effects of conventional systemic antipsoriatic drugs by switching to biologics for a certain period of time as part of rotational therapy or combined therapy strategies.
Clinical Assessment of Disease Severity in Patients with Psoriasis Clinical Assessment of Disease Severity in Patients with Psoriasis Новинка

Clinical Assessment of Disease Severity in Patients with Psoriasis

Psoriasis is a chronic disorder characterized by erythematous scaly patches which affect the scalp, trunk, extensor surfaces of the limbs, and the genital area. Psoriasis is highly prevalent in the general population (0.5% to 4%, depending on the geographic location). Patients with psoriasis have decreased quality of life and high rates of depression, and frequently attend dermatology clinics. The Psoriasis Area and Severity Index (PASI) score is used for the assessment of psoriasis severity, but its disadvantages exceed its advantages by far. During my residency training in dermatology, I identified the lack of an appropriate scale of severity for routine clinical assessment of psoriasis. Thus, I came up with the idea to devise a simple and useful instrument aimed to assess the severity of psoriasis. In 2002, I began to design the first draft of an instrument aimed at evaluating psoriasis severity. The instrument incorporated various factors that determine the physical and psychological impact of psoriasis and was named the "Beer-Sheva Psoriasis Severity Score" (BPSS).
Efficacy of Ayurveda In The Management of Psoriasis Efficacy of Ayurveda In The Management of Psoriasis Новинка

Efficacy of Ayurveda In The Management of Psoriasis

Psoriasis is a chronic and frequently recurring disease which is very difficult to treat.In the present treatment, there are number of hazardous side effects. These factors persuaded the need of Ayurvedic drug research in psoriasis. In Kushtha Chikitsa, Charaka has prescribed repeated shodhana karma to cure the disease. Also the better effect of shamana drugs, given after shodhana karma emphasizes the efficacy of Panchakarma. The book deals with the role of classical Ayurvedic line of treatment in management of psoriasis which starts with shodhana (bio-purification) and shaman(Suppressing) therapy. Hope this book will be helpful to the researchers.
Panchakarma & Herbo-mineral compound for Psoriasis Panchakarma & Herbo-mineral compound for Psoriasis Новинка

Panchakarma & Herbo-mineral compound for Psoriasis

Psoriasis is a relatively common skin disease affecting 1% to 2% of the population. In India an estimated 0.8% population is suffering from Psoriasis. It is a papulo-squamous disorder of the skin, characterized by sharply defined erythematosquamous lesions. It is notoriously chronic and is well known for its course of remission and exacerbation. The exact etiology is still unknown. It is difficult to say what psoriasis is in terms of Ayurveda. There is no disease in Ayurveda, which can exactly be correlated with Psoriasis. The description & characteristic features of Mandala Kushtha are near to the Psoriasis of Modern Science. Shodhana (Vamana & Virechana) is reliable to control the disease. The synergistic action of Tikta & Kashaya rasa dominant herbs & minerals are likely to check the etio-pathogenesis of Mandal Kushtha (Psoriasis) and arrest it progress. This work gives overview of the ayurvedic management of skin diseases( psoriasis) and it management by bio purification therapy like Panchakarma (Vamana & Virechana) and some herbo mineral compound
Psoriasis and Coeliac Disease Psoriasis and Coeliac Disease Новинка

Psoriasis and Coeliac Disease

Over the years, medical scientists have been trying to investigate the aetiopathogenesis of psoriasis in an effort to comfort the psoriasis patients from this distressing disease. This book is a small but significant work investigating the association between coeliac disease and psoriasis in northern India. This work is likely to help the investigators as well as the treating clinicians for providing dietary perspective of psoriasis for better patient management. This book will also prove useful for those readers who are looking for brief but complete overview of psoriasis.
Ноутбук ASUS ROG ZEPHYRUS GX 501 VS-GZ 061 T черный (90 NB0H 11-M 00600) Ноутбук ASUS ROG ZEPHYRUS GX 501 VS-GZ 061 T черный (90 NB0H 11-M 00600) Новинка

Ноутбук ASUS ROG ZEPHYRUS GX 501 VS-GZ 061 T черный (90 NB0H 11-M 00600)

Тип процессора: Intel Core i7 Жесткий диск (гб): 1024 Гарантия: 2 года Размер оперативной памяти (гб): 16 Операционная система: Windows 10 Home Страна-производитель: Китай Размер дисплея (quot;): 15,6
Ноутбук ASUS G 752 VS-BA 228 T (90 NB0D 71-M 03460) Ноутбук ASUS G 752 VS-BA 228 T (90 NB0D 71-M 03460) Новинка

Ноутбук ASUS G 752 VS-BA 228 T (90 NB0D 71-M 03460)

Тип процессора: Intel Core i7 Жесткий диск (гб): 1000 256 Гарантия: 2 года Размер оперативной памяти (гб): 8 Операционная система: Windows 10 Home Страна-производитель: Китай Размер дисплея (quot;): 17.3
Bacteriological and Immunological Aspects of Psoriasis Bacteriological and Immunological Aspects of Psoriasis Новинка

Bacteriological and Immunological Aspects of Psoriasis

This study was conducted to shed light on the role of bacteria in inducing and/or aggravating psoriasis. Staph. aureus was the major bacterial species that was reported singly from psoriatic lesions.The enterotoxigenicity of Staph. aureus that was isolated from psoriatic lesions is detected for the first time in Iraq. Such detection is made to clarify the role of these enterotoxigenic Staph. aureus in the pathogenesis of psoriasis. An In Vivo attempt to induce psoriatic skin lesions with BALB/C mice was performed. The current study has confirmed an increase in the mean percentages of studied serum immunological parameters. In conclusion, the present study assumed that Staph. aureus superantigen play an important role in inducing and triggering of psoriatic lesions and further more sophisticated study on genetically engineered mice is advisable to clarify the exact role.
Psoriasis: Paraoxonase and Lipoprotein (a) Role Psoriasis: Paraoxonase and Lipoprotein (a) Role Новинка

Psoriasis: Paraoxonase and Lipoprotein (a) Role

Psoriasis is a common chronic skin disorder with prevalence of 2.7% in Iraqi community. Psoriasis is a skin disease that it's prevalence affected by many factors which include genetic, environmental, infectious, immunological, biochemical, endocrinological and psychological. Psoriasis is a chronic inflammatory disease with unknown exact pathogenesis, which may be started as skin condition that subsequently associated with systemic complications. The recurrent proliferative inflammatory processes in subject with psoriasis may lead to abnormal lipid metabolism and associated with cardiovascular diseases.
Molecular Weight of Keratin, Amino Acids in Psoriatic patients by HPLC Molecular Weight of Keratin, Amino Acids in Psoriatic patients by HPLC Новинка

Molecular Weight of Keratin, Amino Acids in Psoriatic patients by HPLC

Psoriasis is a long lasting scaling and inflammatory skin disease. Bible and Greeks identified this disease long time before. Psoriasis sufferers in United States population are about three to four percent and near about five million adults of both genders are affected. Psoriasis can be interpreted as a defective reaction of the skin to the injury instead of normal cornification, the cell division rate in the epidermis increases to five times in comparison to its normal level with formation of a pathological stratum corneum. This book will provide a basic guide line in the prevention and cure of the Psoriasis. Silvery white scales erosion seen on the top of the skin needed treatment. Male and female subjects are equally affected at any age. The remedies, diet control, nutritional supplements and certain drugs mention may help to reduce the problem even completely cure the Psoriasis. This book provides latest research, information with regard to the molecular weight of keratin, Genes responsible for this disorder and the amino acids variables present in epidermal keratin of normal and affected skin.
AVX Versus AVX Versus Новинка

AVX Versus

Marvel's greatest super teams engage in full-on battle in this premiere tie-in to Avengers Versus X-Men! Features all-out action covering and expanding on the battles in Avengers Versus X-Men. Such as Iron Man vs. Magneto! Thing vs. Namor! Spider-Man vs. Colossus! Captain America vs. Gambit! and many more...
Application of Leech Therapy and Khadir in Psoriasis Application of Leech Therapy and Khadir in Psoriasis Новинка

Application of Leech Therapy and Khadir in Psoriasis

The skin and skin disorders are beautifully described in Ayurvedic literatures.Scholars have described all the skin diseases under the umbrella of ‘Kushtha’, further classifying them to ‘Mahakushtha’ and ‘kshudra kushtha’. Psoriasis is the oldest recorded skin disease. The disease ranks with Acne vulgaris, Viral warts and eczema as one of the commonest skin. It is a common, chronic, genetically determined, inflammatory and proliferative skin disease. Although not fatal, but is cosmetically unacceptable and cause a lot of mental agony and stress to the patient. Leech therepy is a purificatory and rejuvenative measure for the treatment of chronic diseases. This therapy is easy to administer, does not require any sophisticated instruments for application and rarely produces any complication. Ancient ayurvedic scholars have mentioned that it can be very easily administered in fearful patients as well as in patients of all age groups. Therefore, it is emerging as highly demanding therapy now- a-days. Khadir has also been mentioned to have rasayan property. It is best and broad spectrum drug for the treatment of various skin diseases including Psoriasis.
Are psoriasis & metabolic syndrome offshoots of the same root? Are psoriasis & metabolic syndrome offshoots of the same root? Новинка

Are psoriasis & metabolic syndrome offshoots of the same root?

" Are psoriasis and metabolic syndrome offshoots of the same root?" is a small exercise to make a scientific understanding of etiological association of the two processes. Although a good beginning, still lot of research is needed in this field. C-reactive protein, a marker of inflammation, can be used to sort out those psoriatic patients who are likely to benefit from therapy by biological agents and can also help to delineate those psoriatic patients who are at high risk of developing a metabolic syndrome.
Renal Replacement Therapy in critical Care Renal Replacement Therapy in critical Care Новинка

Renal Replacement Therapy in critical Care

This comprehensive book covers all clinical aspects of renal replacement therapy in critical care. It focuses in particular on continuous renal replacement therapy including detailed and updated information on regional citrate anticoagulation, antibiotic dosing, nutrition, electrolyte monitoring, and novel dialysis membranes. Chapters are dedicated to the Stewart acid-base approach which offers a different but practical insight on metabolic complications during (continuous) renal replacement therapy, and the current status of blood purification during sepsis. Specific modalities such as plasmafiltration and treatment of acute poisoning are also discussed.
New Bee NB-L1 8 Pin In-ear HiFi Music Earphones with Mic-Bronze New Bee NB-L1 8 Pin In-ear HiFi Music Earphones with Mic-Bronze Новинка

New Bee NB-L1 8 Pin In-ear HiFi Music Earphones with Mic-Bronze

New Bee NB-L1 8 Pin In-ear HiFi Music Earphones with Microphone for iPhone iPad iPod - Bronze
Methotrexate in Rheumatoid Arthritis Methotrexate in Rheumatoid Arthritis Новинка

Methotrexate in Rheumatoid Arthritis

Affecting approximately one percent of the adult world population, rheumatoid arthritis is the most common inflammatory joint disease. Due to its positive benefit-risk ratio, Methotrexate (MTX) is first-line therapy in rheumatoid arthritis. Although the drug is very effective, the large inter-patient variability regarding efficacy and frequency of adverse events are major drawbacks. The author describes a randomized, double-blinded controlled clinical trial, investigating the role of methotrexate polyglutamates as a marker for clinical response. Based on the detailed analysis of pharmacokinetic parameters, a pharmacokinetic-pharmacodynamic-pharmacogenomic model of MTX was established. MTXPG2, a short-chain polyglutamate, was identified as a potential marker for clinical response. The results, that MTX modulates key cytokines involved in the pathogenesis of the disease, provide important insights into its mode of pharmacological action. This book is directed toward physicians and clinical scientists who want to gain a better unterstanding of the use of MTX in rheumatoid arthritis.
Laser Therapy in Veterinary Medicine: Photobiomodulation Laser Therapy in Veterinary Medicine: Photobiomodulation Новинка

Laser Therapy in Veterinary Medicine: Photobiomodulation

Laser Therapy in Veterinary Medicine: Photobiomodulation is a complete guide to using therapeutic lasers to treat veterinary patients, focusing on practical information. Offers a comprehensive resource for incorporating therapeutic lasers in veterinary practice Focuses on practical information tailored for the veterinary clinic Written by 37 leading experts in veterinary laser therapy Provides a thorough foundation on this standard-of-care modality Emphasizes clinical applications with a real-world approach
The Psoriasis Cure The Psoriasis Cure Новинка

The Psoriasis Cure

The Psoriasis Cure
Understanding Play Therapy Understanding Play Therapy Новинка

Understanding Play Therapy

The book titled 'Understanding Play Therapy' is a quite good and handy literature for learning, teaching and practicing play therapy on children, adolescents, adults as well as persons with special needs. It provides good information in relation to historical foundation upto current status of play therapy. The students, interns and qualified professionals of clinical psychology, child psychology and developmental psychology and other health professionals of pediatrics can use this book as a good source of learning play therapy and its applications in health intervention as well as non-clinical behavioural problems. In addition, the book also includes how parents can be useful and helpful while dealing with children through play therapy. The author's approach in presenting the issues related to play therapy is praiseworthy as it ensures a comprehensive understanding of play therapy for knowledge and practice.
Sensory Integration Therapy in Children with ASD Sensory Integration Therapy in Children with ASD Новинка

Sensory Integration Therapy in Children with ASD

Autism is a challenging pediatric disorder.Only medication cannot show detrimental improvements. There is always need of a combined therapy in autism.The importance and effects of multimodal therapy especially sensory integration therapy and cognitive behavioral therapy are still not comprehensible and need to be studied. This study engrossed on sensory integration therapy. It holds promise as an effective intervention for individuals with autism.
Deborah Trendel-Leader IV Therapy For Dummies Deborah Trendel-Leader IV Therapy For Dummies Новинка

Deborah Trendel-Leader IV Therapy For Dummies

The fast and painless way to ace your IV Therapy course Are you an aspiring nurse, nurse practitioner, or physician's assistant struggling with IV therapy? Help is here! IV Therapy For Dummies tracks to a typical IV therapy course and gives you current, easy-to-follow guidance on everything you'll encounter in class, such as delivery methods, flow rates, legal issues, profession standards, and documentation. IV Therapy For Dummies also discusses the necessary components of peripheral and central venous therapy, including access sites, equipment, preparation, maintenance, and the discontinuation of therapy. Plus, you'll get the 4-1-1 on the administration of IV medications, including special considerations for pediatric, elderly, and home care patients. Tracks to a typical IV Therapy course Provides current, comprehensive information in plain English If you're enrolled in an IV Therapy course or a healthcare worker looking for a refresher on this important form of medical treatment, IV Therapy For Dummies has you covered.
Thiol Protease Inhibitors from Mammalian lungs Thiol Protease Inhibitors from Mammalian lungs Новинка

Thiol Protease Inhibitors from Mammalian lungs

The estimation of pharmacokinetics and pharmacodynamics of drugs used in the leukaemia multidrug therapy is of great importance. The multidrug therapy of high effectiveness carries the risk of side effects and an increase of therapeutic action of free fractions of drugs. This can be dangerous when exhibiting toxic effect. Regulation of cysteine proteinases and their inhibitors are of utmost importance in diseases like lung cancer, chronic inflammatory conditions such as asthma, emphysema, and idiopathic pulmonary fibrosis. Protease-antiprotease imbalance accelerates disease progression. In the present study, Thiol Protease inhibitors was purified from Lungs using simple and efficient chromatographic techniques. Further, the effect of methotrexate (MTX) (an antineoplastic and antirheumatic) drug on lung cystatin was studied to explore the drug induced protein dysfunction. In addition, we have studied the effect of free radicals on thiol protease inhibitors and their preventive measurement by Polyphenols like Curcumin and Quercetin. Finally we have reported the toxicity of Cigarette smoke on thiol protease inhibitors implicated in cardiovascular disease and Emphysema.
Six Key Approaches to Counselling and Therapy Six Key Approaches to Counselling and Therapy Новинка

Six Key Approaches to Counselling and Therapy

A text for use on introductory courses in counselling and therapy theory and practice. It presents two approaches selected from each of the three main schools influencing contemporary therapy practice: the psychodynamic school, the humanistic school, and the cognitive-behavioural school.
Chang Jeff Basic Family Therapy Chang Jeff Basic Family Therapy Новинка

Chang Jeff Basic Family Therapy

The challenge facing the authors of texts that address the multiplicity and complexity of problems that may afflict families can be intimidating. Philip Barker has addressed this challenge head-on in each of the editions of this book. This task has been greatly facilitated by the contributions of the new co-author, Jeff Chang, and in this edition provides a clear, easily read and readily understandable introduction to family therapy. Much has happened in the field of family therapy since the fifth edition of Basic Family Therapy was published in 2007. New developments covered in this book include: Emotionally Focused Therapy The Gottman approach to couples therapy Mindfulness and psychotherapy The common factors approach to psychotherapy and to family therapy The increased emphasis on empirically supported treatments High-conflict post-divorce parenting Basic Family Therapy will be of value to readers new to family therapy and to those in the early stages of training.
Лак для ногтей Sally Hansen Color Therapy™ 180 (Цвет 180 Chai On Life variant_hex_name EBC9B1) Лак для ногтей Sally Hansen Color Therapy™ 180 (Цвет 180 Chai On Life variant_hex_name EBC9B1) Новинка

Лак для ногтей Sally Hansen Color Therapy™ 180 (Цвет 180 Chai On Life variant_hex_name EBC9B1)

Представляем цветотерапию от Sally Hansen - новые ультрасовременные лаки для ногтей с уходом. Лаки для ногтей Color Therapy от Sally Hansen содержат запатентованную формулу из микро-частиц, которые питают ногти аргановым маслом, оказывая, таким образом, питательное воздействие и незамедлительное увлажнение. 9 из 10 женщин отметили значительное улучшение ногтей после использования лаков Color Therapy™.   ПРИМЕНЕНИЕ: Шаг 1: нанесите один слой Color Therapy™ на чистые сухие ногти и дайте подсохнуть в течение 2–3 минут. Шаг 2: нанесите второй слой Color Therapy™ и дайте высохнуть полностью. Наслаждайтесь блестящим маникюром салонного качества и роскошными оттенками, доступными в различных цветовых палитрах до 10 дней без выцветания и трещин.   Объем 14.7 мл.
Charles Schaefer E. Foundations of Play Therapy Charles Schaefer E. Foundations of Play Therapy Новинка

Charles Schaefer E. Foundations of Play Therapy

The landmark guide to play therapy—completely updated and revised Edited by Charles E. Schaefer—the «father of play therapy»—Foundations of Play Therapy, Second Edition is a complete, state-of-the-art guide to the many diverse approaches to, and methods used in, play therapy practice with children and adolescents. Featuring an expert panel of contributors, this comprehensive reference provides up-to-date and insightful coverage of all of the major theoretical models of play therapy and offers practical examples for the application of each model, including: Narrative play therapy Solution-focused play therapy Experiential play therapy Release play therapy Integrative play therapy Psychoanalytic approaches to play therapy Child-centered play therapy Gestalt play therapy Family play therapy Cognitive behavioral play therapy Prescriptive play therapy Written for therapists looking for guidance on how to incorporate play therapy into their practice, as well as students or those in need of a refresher on the latest methods and techniques, Foundations of Play Therapy, Second Edition is a standard-setting resource presenting pragmatic and useful information for therapists at all levels of training.
The Oxford Handbook of Music Therapy The Oxford Handbook of Music Therapy Новинка

The Oxford Handbook of Music Therapy

Music therapy is growing internationally to be one of the leading evidence-based psychosocial allied health professions to meet needs across the lifespan.The Oxford Handbook of Music Therapy is the most comprehensive text on this topic in its history. It presents exhaustive coverage of the topic from international leaders in the field
New Bee NB-7 Earbuds Black New Bee NB-7 Earbuds Black Новинка

New Bee NB-7 Earbuds Black

New Bee NB-7 Bluetooth 4.1 Stereo Earbuds Earphone Heaset with Built-in Microphone - Black
New Bee NB-7 Earbuds Green New Bee NB-7 Earbuds Green Новинка

New Bee NB-7 Earbuds Green

New Bee NB-7 Bluetooth 4.1 Stereo Earbuds Earphone Heaset with Built-in Microphone - Green
Osteoarthritis and gene therapy Osteoarthritis and gene therapy Новинка

Osteoarthritis and gene therapy

Osteoarthritis (OA) is the most common chronic joint disease in the world. Pathological changes in all joint tissues are the impetus for considering OA as a disease of the joint ‘as an organ’, resulting in joint failure. Although the management of OA remains under-provided, this book provides a new insight on the future of gene therapy after going through the preceding advances in therapeutic discoveries. An overview of the role of gene therapy in other rheumatic diseases was considered. This book presents a comprehensive description of the basics of OA and gene therapy with in-depth discussion. It provides advanced information of such a mysterious and interesting therapeutic approach. The book is designed to provide a useful and informative overview for rheumatology students and professionals and the material included is sufficient to serve as a reference for clinicians dealing with OA patients. The readers will take a worthy idea on the disease, updates in medical treatments and the advanced concepts in its management. This book should prove useful in throwing light on gene therapy and its role in OA, and in implementing these updates to improve human health and quality of life.
Schaefer Charles E. School-Based Play Therapy Schaefer Charles E. School-Based Play Therapy Новинка

Schaefer Charles E. School-Based Play Therapy

A thorough revision of the essential guide to using play therapy in schools Fully updated and revised, School-Based Play Therapy, Second Edition presents an A-to-Z guide for using play therapy in preschool and elementary school settings. Coedited by noted experts in the field, Athena Drewes and Charles Schaefer, the Second Edition offers school counselors, psychologists, social workers, and teachers the latest techniques in developing creative approaches to utilize the therapeutic powers of play in schools. The Second Edition includes coverage on how to implement a play therapy program in school settings; play-based prevention programs; individual play therapy approaches as well as group play; and play therapy with special populations, such as selectively mute, homeless, and autistic children. In addition, nine new chapters have been added with new material covering: Cognitive-behavioral play therapy Trauma-focused group work Training teachers to use play therapy Filled with illustrative case studies and ready-to-use practical techniques and suggestions, School-Based Play Therapy, Second Edition is an essential resource for all mental health professionals working in schools.
New Bee NB-7 Earbuds Red New Bee NB-7 Earbuds Red Новинка

New Bee NB-7 Earbuds Red

New Bee NB-7 Bluetooth 4.1 Stereo Earbuds Earphone Heaset with Built-in Microphone - Red
Лак для ногтей Sally Hansen Color Therapy™ 290 (Цвет 290 Pampered in Pink variant_hex_name EA3067) Лак для ногтей Sally Hansen Color Therapy™ 290 (Цвет 290 Pampered in Pink variant_hex_name EA3067) Новинка

Лак для ногтей Sally Hansen Color Therapy™ 290 (Цвет 290 Pampered in Pink variant_hex_name EA3067)

Представляем цветотерапию от Sally Hansen - новые ультрасовременные лаки для ногтей с уходом. Лаки для ногтей Color Therapy от Sally Hansen содержат запатентованную формулу из микро-частиц, которые питают ногти аргановым маслом, оказывая, таким образом, питательное воздействие и незамедлительное увлажнение. 9 из 10 женщин отметили значительное улучшение ногтей после использования лаков Color Therapy™.   ПРИМЕНЕНИЕ: Шаг 1: нанесите один слой Color Therapy™ на чистые сухие ногти и дайте подсохнуть в течение 2–3 минут. Шаг 2: нанесите второй слой Color Therapy™ и дайте высохнуть полностью. Наслаждайтесь блестящим маникюром салонного качества и роскошными оттенками, доступными в различных цветовых палитрах до 10 дней без выцветания и трещин.   Объем 14.7 мл.
REFOCUSSING: A GOD-BASED THERAPY METHOD REFOCUSSING: A GOD-BASED THERAPY METHOD Новинка

REFOCUSSING: A GOD-BASED THERAPY METHOD

There is a growing and significant interest in the effects of a person''s spiritual and religious beliefs and experiences on their psychological well- being. Alongside this growing interest has emerged the development of therapy methods which acknowledge and attempt to utilise this effect. Refocussing Therapy, developed by Dr Diane Divett, is one such method. This book provides an insight into Refocussing Therapy''s theoretical context, and analyzes and explores its effectiveness. While shedding light on the benefits of this unique therapy method, this book also investigates the impact upon mental health of the kind of God we believe in. The implications for clinical practice should be useful and intriguing to professionals working in the mental health field as well as those working directly with people''s spirituality.
LMP 7 gene and response to IFN-therapy in HCV infected patients LMP 7 gene and response to IFN-therapy in HCV infected patients Новинка

LMP 7 gene and response to IFN-therapy in HCV infected patients

HCV infection becomes a major health problem. So there is a need for improvements in diagnosis, prognosis and treatment of the disease. In this book, we concerned with studying biomarkers that can be used to help in detection of the progression of disease and prediction of the response to IFN-therapy. The book included a study on the relationship between the LMP 7 gene polymorphism and response to IFN-therapy in the Egyptian HCV infected patients. The study found a great association between the response to IFN-therapy in HCV infected patients and LMP 7 gene. so, the LMP 7 gene can be used as a biomarker for prediction of response to IFN-therapy.
Methotrexate and Hepatotoxicity in Rheamatoid Arthritis Patients Methotrexate and Hepatotoxicity in Rheamatoid Arthritis Patients Новинка

Methotrexate and Hepatotoxicity in Rheamatoid Arthritis Patients

The book will launch a new skylight for those who are inquisitive for acquiring knowledge in the field Medical science. By dint of this book one can get access to know that rheumatoid arthritis leads to long term damage resulting in chronic pain, loss of function and disability but the drug Methotrexate halts the disease process and causes symptomatic relieves whereas most other drugs relives merely symptoms.
Low Level Laser Therapy Effect on Growth Factors in Wound Healing Low Level Laser Therapy Effect on Growth Factors in Wound Healing Новинка

Low Level Laser Therapy Effect on Growth Factors in Wound Healing

This book represent a new challenge in the Laser therapy field. It takes the effect of diode laser on the healing of wound from a molecular level by using immunohistochemical staining technique which represent one of the most advanced method used in histology and pathology. Low Level Laser effect on the biological tissue still need for further studies and by using immunohistochemistry the answers of many questions could be found.
Sequential Therapy and triple Therapy in Eradication of H. Pylori Sequential Therapy and triple Therapy in Eradication of H. Pylori Новинка

Sequential Therapy and triple Therapy in Eradication of H. Pylori

This book compared the effectiveness of sequential therapy to standard triple therapy in the eradication of Helicobacter Pylori which is the main known cause of gastritis gastro-duodenal ulcer disease and gastric cancer. However, after more than 20 years of experience in H. pylori treatment, the ideal regimen to treat this infection has still to be found. Currently, apart from having a good knowledge of first-line eradication regimens, clinicians involved in the treatment of diseases caused by this pathogen must also be prepared to accept failures. Therefore, those involved in the design of a treatment strategy should not focus on the results of primary therapy alone, but also the make choices regarding a ‘rescue’ based on the overall eradication rate. According to several international guidelines, the first-line therapy for treating H. pylori infection consists of a proton pump inhibitor with any of two antibiotics, given for a 7–14 day period. However, even with these recommended regimens, H. pylori eradication failure is still observed in more than 20% of patients, and the failure rate of first-line therapy may be higher in clinical practice. Therefore, an alternative sequen
Effect of Ultrasound Therapy on Subserousal & Intramural Fibroids Effect of Ultrasound Therapy on Subserousal & Intramural Fibroids Новинка

Effect of Ultrasound Therapy on Subserousal & Intramural Fibroids

Using ultrasound therapy has a significant effect in shrinking the size of subserosal and intramural uterine fibroids and consequently, improving these symptoms related to it such as uterine bleeding, chronic pelvic pain & urination disorders depending on benefit from thermal effect is produced by non-invasive US therapy to keep away from operative selections was to be used in the treatment of uterine fibroids.
Preparation of pediatric patients for treatment with proton beam therapy Preparation of pediatric patients for treatment with proton beam therapy Новинка

Preparation of pediatric patients for treatment with proton beam therapy

Proton beam therapy is considered to reduce the toxicity for pediatric patients. However, many pediatric patients need anesthesia and longer occupancy time of treatment room. This book shows the knack of preparation base on the experience of two major pediatric radiation oncologist in Japan. This book makes it possible to perform proton beam therapy more smoothly. In the result, the burden on patients decreased and treatable patients increased.
Mathematical Model of Tumour Therapy by Biochemotherapy Mathematical Model of Tumour Therapy by Biochemotherapy Новинка

Mathematical Model of Tumour Therapy by Biochemotherapy

Tumour is a lethal disease in this world. There are many possible approaches to treating tumours, such as immunotherapy, chemotherapy and biochemotherapy. Nowadays, many clinicians and researchers develop methods to deal with this disease. Basic concepts and mathematical analysis of tumour therapy present in this book. Simulation of the tumour therapy also presents in this book. This book is relevant to students and researchers who studying about tumour therapy or clinicians that doing experiment tumour therapy. This book will help students and researchers to understand the process of tumour therapy and will give the benefit for clinicians in predicting results through mathematical modeling prior to commencing treatment on human subjects, it will minimize the dangerous effect and the cost of treatment.
Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Honeysuckle & Peach (Объем 500 мл) Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Honeysuckle & Peach (Объем 500 мл) Новинка

Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Honeysuckle & Peach (Объем 500 мл)

Линия свежих ароматов, вдохновленных природой. Уникальная формула, в основе которой лежат только безопасныеингредиенты, создает игристую пену, которая обладает нежным фруктово-цветочным ароматом. Специальныеувлажняющие компоненты мягко очищают вашу кожу, делая ее мягкой и здоровой.   Не содержит Парабенов, Фталатов, Гликоля Пропилена, Нефти, Искусственных красителей, Глютена.   Поддерживает естественный pH баланс кожи.   Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качестве геля для душа, шампуня для волос или пены для ванны на ваше личное усмотрение.   Сочный и свежий аромат персика и жимолости подарит Вам хорошее настроение на весь день, а специально подобранные ингредиенты придадут мягкость коже и шелковистость Вашим волосам.   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы
Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Sweet Vanilla (Объем 500 мл) Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Sweet Vanilla (Объем 500 мл) Новинка

Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Sweet Vanilla (Объем 500 мл)

Линия Dee-lish – это «съедобные» ароматы для истинных гурманов. Устройте себе праздник и искупайтесь в настоящихлакомствах.   Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качестве геля длядуша, шампуня для волос или пены для ванны на ваше личное усмотрение, а экономичный объем 500 мл позволит вампользоваться любимым продуктом еще дольше.   Соблазнительный аромат ванили расслабляет, дарит Вам ощущение бесконечного удовольствия и улучшает настроение! Специально подобранные ингредиенты придают мягкость коже и шелковистость Вашим волосам.   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы
Для детей Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Citrus Splash (Объем 950 мл) Для детей Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Citrus Splash (Объем 950 мл) Новинка

Для детей Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Citrus Splash (Объем 950 мл)

Почувствуйте заряд бодрости с невероятно свежей линией Джуси. Ароматы сочных фруктов подарят вам ощущение свежести на весь день, а безопасный состав продуктов бережно и нежно очистит вашу кожу, придав ей мягкость и упругость. Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качествегеля для душа, шампуня для волос или пены для ванны на ваше личное усмотрение, а экономичный объем 950 мл позволит вам пользоваться любимым продуктом еще дольше.   Свежий и бодрящий аромат цитрусовых подарит Вам заряд энергии на весь день, а специально подобранные ингредиенты придадут мягкость коже и шелковистость Вашим волосам.   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы- Экономичный объем 950 мл  
Гель для душа Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Coconut Maui (Объем 500 мл) Гель для душа Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Coconut Maui (Объем 500 мл) Новинка

Гель для душа Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Coconut Maui (Объем 500 мл)

Ощутите райское наслаждение с новой линий по уходу за телом и волосами – Эскейп. Уникальные безопасные компоненты бережно позаботятся о вашей коже, а экзотические ароматы перенесут вас на далекие острова.   Не содержит Парабенов, Фталатов, Гликоля Пропилена, Нефти, Искусственных красителей, Глютена.   Поддерживает естественный pH баланс кожи.   Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качестве геля для душа, шампуня для волос или пены для ванны на ваше личное усмотрение.   Получите поистине райское наслаждение с чувственным ароматом Гибискуса. Средство cодержит смягчающиеингредиенты и позволят навсегда забыть о сухости и шелушении кожи.   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы
Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Peony & Pear (Объем 500 мл) Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Peony & Pear (Объем 500 мл) Новинка

Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Peony & Pear (Объем 500 мл)

Линия свежих ароматов, вдохновленных природой. Уникальная формула, в основе которой лежат только безопасныеингредиенты, создает игристую пену, которая обладает нежным фруктово-цветочным ароматом. Специальныеувлажняющие компоненты мягко очищают вашу кожу, делая ее мягкой и здоровой.   Не содержит Парабенов, Фталатов, Гликоля Пропилена, Нефти, Искусственных красителей, Глютена.   Поддерживает естественный pH баланс кожи.   Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качестве геля для душа, шампуня для волос или пены для ванны на ваше личное усмотрение.   Изысканный и соблазнительный аромат пиона и груши наполнит Ваш день яркими красками, а специально подобранные ингредиенты придадут мягкость коже и шелковистость Вашим волосам.   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы
Гель для душа Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Tiare Tahiti (Объем 500 мл) Гель для душа Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Tiare Tahiti (Объем 500 мл) Новинка

Гель для душа Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Tiare Tahiti (Объем 500 мл)

Ощутите райское наслаждение с новой линий по уходу за телом и волосами – Эскейп. Уникальные безопасные компоненты бережно позаботятся о вашей коже, а экзотические ароматы перенесут вас на далекие острова.   Не содержит Парабенов, Фталатов, Гликоля Пропилена, Нефти, Искусственных красителей, Глютена.   Поддерживает естественный pH баланс кожи.   Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качестве геля для душа, шампуня для волос или пены для ванны на ваше личное усмотрение.   Восхитительный и чувственный аромат Тиаре погрузит вас в мир удовольствий и наслаждений. Средство cодержит смягчающие ингредиенты и позволят навсегда забыть о сухости и шелушении кожи.   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы
Для детей Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Raspberry Twist (Объем 950 мл) Для детей Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Raspberry Twist (Объем 950 мл) Новинка

Для детей Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Raspberry Twist (Объем 950 мл)

Почувствуйте заряд бодрости с невероятно свежей линией Джуси. Ароматы сочных фруктов подарят вам ощущение свежести на весь день, а безопасный состав продуктов бережно и нежно очистит вашу кожу, придав ей мягкость и упругость. Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качествегеля для душа, шампуня для волос или пены для ванны на ваше личное усмотрение, а экономичный объем 950 мл позволит вам пользоваться любимым продуктом еще дольше.   Аппетитный аромат малины подарит Вам хорошее настроение на весь день, а специально подобранные ингредиенты придадут мягкость коже и шелковистость Вашим волосам.   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы- Экономичный объем 950 мл  
Breast cancer treatment by targeting breast cancer stem cells Breast cancer treatment by targeting breast cancer stem cells Новинка

Breast cancer treatment by targeting breast cancer stem cells

This research focuses on gene therapy as well as immunotherapy to target the breast cancer stem cells in breast cancer treatment. Breast cancer stem cells were isolated and proliferated from malignant breast tumors. About gene therapy, we used knockdown gene therapy to suppress the CD44 expression. CD44 holds an important role in stemness maintenance of breast cancer stem cells. CD44 down regulation makes breast cancer stem cells sensitize to anti-tumor drug (doxorubicin). So that combinatorial therapy of CD44 down-regulation and doxorubicin strongly suppressed the tumor growth in NOD/SCID mice. In another way, we used dendritic cell therapy to target breast cancer stem cells. Dendritic cells were loaded with breast cancer stem cells derived antigens. The results also showed that dendritic cell vaccination inhibits the cancer development in mice models.
Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Wildberry Smoothie (Объем 500 мл) Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Wildberry Smoothie (Объем 500 мл) Новинка

Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Wildberry Smoothie (Объем 500 мл)

Линия Dee-lish – это «съедобные» ароматы для истинных гурманов. Устройте себе праздник и искупайтесь в настоящихлакомствах.   Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качестве геля длядуша, шампуня для волос или пены для ванны на ваше личное усмотрение, а экономичный объем 500 мл позволит вампользоваться любимым продуктом еще дольше.   Притягательные, вкусные и соблазнительные ароматы сочных ягод дарят заряд энергии на весь день! Специальноподобранные ингредиенты придают мягкость коже и шелковистость Вашим волосам   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы
Vascular Medicine: Therapy and Practice Vascular Medicine: Therapy and Practice Новинка

Vascular Medicine: Therapy and Practice

Vascular Medicine, Second Edition presents the current methods of diagnosis and treatment across the entire specialty of angiology, providing clear guidance on vascular medicine from well-known specialists. Updates include coverage of recent advances in endovascular therapy, an introductory anatomy section in each chapter, and a detailed duplex ultrasonography section for every vascular region. This new edition also contains chapters on the increasingly important areas of acute stroke treatment and renal sympathectomy, each written by leading experts in those treatment methods.Key Features:Focuses on the medical as well as the surgical aspects of angiologyComplete coverage of all three treatment options: conservative treatment, endovascular therapy, and surgeryInterdisciplinary approach that includes outpatient medicine, vascular medicine, cardiology, and radiologyAll medical specialists involved in vascular medicine, as well as interventional specialists and vascular surgeons, will find this book to be an invaluable reference throughout their careers.
Comprehensive Occupational Therapy for Rheumatoid Arthritis Comprehensive Occupational Therapy for Rheumatoid Arthritis Новинка

Comprehensive Occupational Therapy for Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic disabling joint disease. Empowering patients with RA to self manage the disease can lead to changes in behaviour, pain or physical health and psychosocial health status. Limited evidence exists for the efficacy of comprehensive Occupational Therapy (OT) intervention for patients with RA in improving functional ability. This study aimed to evaluate the impact of comprehensive OT intervention on patients with RA in producing a sustained improvement in patients' functional ability. It was found that a comprehensive in-patient occupational therapy programme does lead to sustained significant improvement in functional ability and Health related quality of life (HR-QOL). Focus groups and home based intervention appears to have a clinically significant impact on disease activity.
Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Strawberries-n-Cream (Объем 500 мл) Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Strawberries-n-Cream (Объем 500 мл) Новинка

Шампунь Bath Therapy 3-in-1 Body Wash, Bubble Bath & Shampoo Strawberries-n-Cream (Объем 500 мл)

Линия Dee-lish – это «съедобные» ароматы для истинных гурманов. Устройте себе праздник и искупайтесь в настоящихлакомствах.   Средство 3 в 1 это удобное и экономичное решение, которое позволяет использовать продукт в качестве геля длядуша, шампуня для волос или пены для ванны на ваше личное усмотрение, а экономичный объем 500 мл позволит вампользоваться любимым продуктом еще дольше.   Окунитесь в изысканное сочетание клубники и сливок и почувствуйте прикосновение нежности. Ваши кожа и волосыостанутся вам благодарны за такое наслаждение.   - Безопасный состав- Нейтральный для кожи pH- Гипоаллергенные ароматы
Epidemiology of Melioidosis in Sabah Epidemiology of Melioidosis in Sabah Новинка

Epidemiology of Melioidosis in Sabah

Research Monograph on Burkholderia pseudomallei. This research monograph presents important information on Epidemiology of Melioidosis in Sabah, Malaysia. With emphasis on pathogenesis, clinical presentation, animal melioidosis, laboratory diagnosis, antimicrobial therapy and future directions. The monograph will be useful to medical scientists, researchers, and lecturers in Medical Microbiology.
Глаза и губы Secret Nature Cactus Therapy Eye Roll On (Объем 15 мл) Глаза и губы Secret Nature Cactus Therapy Eye Roll On (Объем 15 мл) Новинка

Глаза и губы Secret Nature Cactus Therapy Eye Roll On (Объем 15 мл)

Разглаживающая роллер-сыворотка для кожи вокруг глаз с кактусом.   Интенсивная сыворотка для ухода за нежной кожей глаз содержит экстракт мексиканского кактуса, опунции индийской, богатой антиоксидантами и витаминами. Сыворотка идеально подходит для ухода за нежной кожей глаз, повышая эластичность кожи, уменьшая гиперпигментацию и отечность вокруг глаз.  * На 87% состоит из ингредиентов натурального происхождения.*Массаж кожи специальной роликовой насадкой улучшит эффект от сыворотки, успокаивая кожу вокруг глаз и улучшая микроциркуляцию.   СПОСОБ ПРИМЕНЕНИЯ: Мягко надавите на тюбик под роликовой насадкой. При помощи роликовой насадки промассируйте круговыми движениями кожу вокруг глаз. Затем постукивающими движениями подушечками пальцев пройдитесь по коже вокруг глаз для улучшения впитывания сыворотки.   МЕРЫ ПРЕДОСТОРОЖНОСТИ: Хранить вдали от детей. Не для пищевых целей. Не использовать по истечении срока годности. Не подвергать воздействию прямого солнечного света.
Psoriatic Arthritis Psoriatic Arthritis Новинка

Psoriatic Arthritis

Psoriatic arthritis shows wide range of radiological skeletal changes. The most commonly sites involved are "bare area" erosions of distal interphalangeal joints of fingers and inter phalangeal joints of great toe. The most common radiological findings are erosion in hands and new bone formation in feet. In spine dorsolumbar region is commonly involved in form of coarse, asymmetrical syndemophytes. Articular erosions is a common findings in sacroiliac joints. In routine, radiological assessment is not done in psoriatic cases with or without arthritis. It is of the opinion that every patient of psoriasis must be subjected to radiological examination so as to detect arthritis at an early stage,to start early aggressive therapy and to stop the progression of joint destruction and disability.
Natural Killer Cells and Hepatitis C Virus Natural Killer Cells and Hepatitis C Virus Новинка

Natural Killer Cells and Hepatitis C Virus

Innate immunity is thought to contribute to sustained virological response (SVR) to pgylated interferon-?/ribavirin (peg-IFN-?/ribavirin) therapy. Natural killer (NK) cells are implicated in the regulation of a protective immune response in patients chronically infected with HCV. We sought to investigate the level of NK subsets among Egyptian patients with chronic HCV and to analyze the influence of IFN therapy on this level. Samples were collected from chronically infected patients (n= 37) at baseline and from a subset before and after 6 months on peg-IFN-?/ribavirin therapy. NK cells were characterized by flow cytometry. The number of CD3- CD56+ cells was significantly lower in patients with chronic HCV infection before treatment compared to healthy controls, but they increased during IFN therapy. There was a significant increase in the number of CD16+ and CD3- CD56+ cells in patients with sustained virological responses (SVR) during therapy compared to patients are non-responders (NR). Meanwhile, CD56+ cells were significantly increased in patients with chronic HCV infection before treatment compared to healthy controls and decreased during therapy in responders.

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The landmark guide to play therapy—completely updated and revised Edited by Charles E. Schaefer—the «father of play therapy»—Foundations of Play Therapy, Second Edition is a complete, state-of-the-art guide to the many diverse approaches to, and methods used in, play therapy practice with children and adolescents. Featuring an expert panel of contributors, this comprehensive reference provides up-to-date and insightful coverage of all of the major theoretical models of play therapy and offers practical examples for the application of each model, including: Narrative play therapy Solution-focused play therapy Experiential play therapy Release play therapy Integrative play therapy Psychoanalytic approaches to play therapy Child-centered play therapy Gestalt play therapy Family play therapy Cognitive behavioral play therapy Prescriptive play therapy Written for therapists looking for guidance on how to incorporate play therapy into their practice, as well as students or those in need of a refresher on the latest methods and techniques, Foundations of Play Therapy, Second Edition is a standard-setting resource presenting pragmatic and useful information for therapists at all levels of training.
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